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Epigenetic inactivation of genes plays a critical role in many important human diseases, especially in cancer. A core mechanism for epigenetic inactivation of the genes is methylation of CpG islands in genome DNA. Methylation of CpG islands involves the course in which DNA methyltransferases (Dnmts) transfer a methyl group from S-adenosyl-L-methionine to the fifth carbon position of the cytosines. At least three families of Dnmts have been identified in mammals now: Dnmt1, Dnmt2, and Dnmt3. The Dnmt3 family comprises of three different proteins: Dnmt3A, Dnmt3B, and Dnmt3L. Dnmt3A and Dnmt3B have been demonstrated to methylate both unmethylated and hemimethylated DNA equally and supposed to mediate de novo methylation together with Dnmt1. Increased activation or amount of Dnmt3 is believed to be involved in carcinogenesis, and other genetic and epigenetic diseases.
https://www.creativebiomart.net/DNMT3B-Assay-Kit-462743.htm
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