3-羟基吡啶工业级 羧酸衍生物 胺类 杂环化合物 手性化合物 2,6-二氨基甲苯

3-Hydroxypyridine is a colorless needle-like crystal. It is soluble in alcohol and water, slightly soluble in ether and benzene. It turns red when mixed with ferric chloride and decomposes easily in air.

Basic Information

• Chinese Name

  3-Hydroxypyridine

• Foreign Name

  3-Hydroxypyridine

• Molecular formula

  C5H5NO

• Molecular Weight

  95.1

3-Hydroxypyridine is a colorless needle-shaped crystal. It is soluble in alcohol and water, slightly soluble in ether and benzene. It turns red when mixed with ferric chloride and decomposes easily in air.

Basic Information

• Chinese Name

  3-Hydroxypyridine

• Foreign Name

  3-Hydroxypyridine

• Molecular formula

  C5H5NO

• Molecular Weight

  95.1

Physical Properties Data

1. Characteristics: Colorless needle-like crystals.

2. Density (g/mL, 20°C): Not determined

3. Relative vapor density (g/mL, air = 1): Not determined

4. Melting Point (°C): 129

5. Boiling Point (°C, Normal Pressure): 280-281

6. Boiling point (°C, kPa): Not determined

7. Refractive index (D20): Not determined

8. Flash Point (°C): 173

9. Optical rotation (°C): Not determined

10. Auto-ignition point or ignition temperature (°C): Not determined

11. Vapor Pressure (mmHg, 20°C): Not Determined

12. Saturated vapor pressure (kPa, ℃): Not determined

13. Heat of combustion (KJ/mol): Not determined

14. Critical Temperature (°C): Not determined

15. Critical Pressure (KPa): Not determined

16. Logarithmic value of the oil/water partition coefficient: Not determined

17. Explosion Upper Limit (%., V/V): Not determined

18. Explosion Lower Limit (%V/V): Not Determined

19. Solubility: Soluble in alcohol and water, slightly soluble in ether and benzene.

折叠Storage Method

Stored in a cool, well-ventilated warehouse. Keep away from sources of ignition and heat sources. Keep containers sealed. Should be stored separately from oxidizing agents, and mixed storage should be avoided. Use explosion-proof lighting and ventilation facilities. The use of mechanical equipment and tools that can generate sparks is prohibited. The storage area should be equipped with emergency response equipment for leaks and appropriate containment materials.

Synthesis Method

Pyridine is obtained through sulfonation, alkali fusion, and neutralization. Pyridine is added to a dry reaction vessel under stirring, followed by the addition of mercury sulfate. The mixture is heated to 230-240°C and maintained for 13-14 hours. Upon cooling to 20-25°C, it is added to ethanol and further cooled to below 5°C, where crystals form. The mixture is filtered to obtain pyridine-3-sulfonic acid. The melting point is 345°C, with a yield of 62%. Sodium hydroxide and pyridine-3-sulfonic acidare added to the reaction vessel, where they melt at 160°C. The mixture is heated to 220-230°C and maintained for 4 hours. Upon cooling to 100°C, the solution is dissolved in water, and the pH is adjusted to 4 with 30% hydrochloric acid. The solution is concentrated under reduced pressure, and the solid sodium chloride is removed by filtration. The filtrate is adjusted to pH 8-9 with saturated sodium carbonate, cooled, filtered, and dried to obtain 3-hydroxypyridine as a crude product, with aYield of 64%. The crude product is recrystallized using toluene to obtain a pure product with a melting point of 126-128°C and a purity of 98%. The refined product has a yield of 80%.

Primary Purpose

Used in organic synthesis, pharmaceutical industry, and the preparation of dyes

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